BOSTON—Jackson Holliday was hitless in four at-bats in his major league debut, but he watched the Baltimore Orioles come from behind for a 7-5 win over the Boston Red Sox before 27,936 at Fenway Park on Wednesday.

Holliday struck out in the third, hit into a fielder’s choice in the fifth, drove in a run on an infield out in the sixth and struck out in the seventh.

Boston (7-5) scored five runs against Oriole starter Cole Irvin. The first one came when Jarren Duran scored from first on a pop single by Tyler O’Neill in the third inning when Holliday retreated to short center on a pop, called for the ball and watched it drop, allowing Duran to sprint home.

Connor Wong had a two-run single in the fourth, and Triston Casas hit a two-run home run in the fifth.

The Orioles had just two hits in the first five innings against Kutter Crawford. Isaiah Campbell gave up three runs in the sixth on a two-run single by leftfielder Colton Cowser, who had four RBIs in Tuesday’s 7-1 win, and on Holliday’s infield out.

In the seventh, Chris Martin (1-1) allowed four runs in a sloppy inning that featured a walk and two wild pitches, a passed ball and catcher’s interference by Wong and a three-run home run by Jordan Westburg that turned a 5-4 Orioles deficit into a 7-5 lead.

Mike Baumann (1-0) pitched a scoreless sixth, striking out three, and Keegan Akin pitched two scoreless innings for the Orioles (7-4). Akin struck out four and walked one and got two fine catches from Cowser in left for the first and third outs in the eighth.

Closer Craig Kimbrel pitched a 1-2-3 ninth, striking out two, for his second save.