NEW YORK— For the second time in three games, Seranthony Dominguez gave up a game-winning home run. Pinch-hitter Jesse Winker hit a 3-2 pitch from Dominguez (3-4) over the left-center field wall to give the New York Mets a 4-3 win over the Orioles before 32,874 at Citi Field on Wednesday.

Edwin Díaz (5-1) pitched a perfect ninth inning for New York.

The Orioles (74-54) lost two of three against the Mets (66-61), and produced little offense, getting just three hits.

Sean Manaea retired the first 17 Orioles to face him before he hit Jackson Holliday with a pitch with two outs in the sixth inning. Austin Slater followed with his first home run with the Orioles to tie it, 2-2.

Cole Irvin, whose contract was selected from Triple-A Norfolk earlier in the day, replaced Zach Eflin who was placed on the 15-day injured list with right shoulder inflammation.

Irvin allowed two runs on five hits in 4 1/3 innings. Francisco Lindor hit his 25^th home run to lead off the third, and a second run charged to Irvin scored on JD Martinez’s fielder’s choice.

Harrison Bader was hit by a pitch, and Vientos singled with one out against Irvin. Colin Selby’s first hitter was Martinez, who grounded into a force play. Selby walked Brandon Nimmo and Pete Alonso to load the bases and struck out Starling Marte to end the inning.

Brandon Hyde has been trying  everything to make sure Craig Kimbrel recaptures the effectiveness of the first half of the season as the Orioles’ closer.

After Kimbrel retired the final two batters in Tuesday night’s game, one that the Orioles won by four runs, Hyde decided to try Kimbrel in a tie game.

He allowed a home run to Mark Vientos in the seventh inning. giving the Mets a 3-2 lead.

Manaea left after Colton Cowser’s leadoff single in the eighth. José Buttó walked Ramón Urias and Holliday. Ryan O’Hearn pinch-hit for Slater, struck out swinging and was ejected for arguing with home plate umpire Marvin Hudson.

Cowser scored on Adley Rutschman’s foul fly ball to left to tie it at 3.