BALTIMORE—The Orioles’ long Yankees nightmare is over. After 19 straight painful defeats, a club record, the Orioles scored four runs in the fifth inning to beat the Yankees, 6-3, in the second game of a doubleheader on Friday night at Camden Yards.

It was the Orioles’ first win over New York since March 31, 2019, and their first at home against the Yankees since July 11, 2018, ending an 18-game losing streak.

“We’ve had a tough time against them,” Orioles manager Brandon Hyde said. “They’re a good club. Game 1 was disappointing because we had opportunities there. We had opportunities in the past as well. We just hadn’t finished it, at least until tonight.”

The Orioles are 17-21.

Rookie leftfielder Ryan Mountcastle, who has been outstanding since his recall from the Bowie alternate site, drove in three runs, including the tying run. He had a two-run home run in the second, his third of the year, and first at home. His RBI single in the fifth keyed the four-run rally.

“I feel like I have something to prove,” said Mountcastle, who also had an infield hit. “I still feel like I can get a little better in some areas.”

Mountcastle is batting .356 after two weeks in the major leagues.

“I just love the athleticism he’s showing,” Hyde said. “He’s showed you the raw power. He’s playing a nice left field. He’s playing hungry, and it’s really, really fun to watch him, a young guy coming up with hype, playing with this much energy and this much confidence. It’s been a big boost.”

The Orioles lost the first game Friday to the Yankees, 6-5, in nine innings, and the defeat stood out because they lost rightfielder Anthony Santander to an oblique injury.

Santander was the only Oriole to play in each of the team’s first 36 games. DJ Stewart started in right field in Game 2.

After Mountcastle’s two-run homer in the second, the Yankees scored a run in the third.

Tyler Wade singled, moved to second on a wild pitch by starter Jorge López and to third on a throwing error by catcher Pedro Severino. Wade scored on an infield out by Thairo Estrada.

López gave up two more runs in the fourth when he walked the leadoff hitter, Brett Gardner and, with two outs, Miguel Andújar grounded to third baseman Rio Ruiz, whose throw to first was offline for a two-base error.

Erik Kratz, the Yankees’ 40-year-old journeyman catcher who has played for nine major league teams, singled to left to score Gardner and Andújar for a 3-2 New York lead.

López pitched five innings, allowing three unearned runs on three hits, and getting his first win since last September 12th when he was with Kansas City.

“That was big, big for us,” Hyde said. “We had very, very. limited options out of the bullpen.

“I thought threw the ball great. He really should have given up no runs.”

The Orioles, who left 11 on base and went 1-for-12 with runners in scoring position in the first game, were more productive in the second game.

With one out in the fifth, Stewart walked and ,after Renato Núñez struck out, Severino singled. Mountcastle singled to score Stewart against Clarke Schmidt, New York’s top draft choice in 2017 who was making his major league debut.

Ruiz’s opposite field single to left scored Severino, and Pat Valaika’s double to right scored Mountcastle and Ruiz, and gave the Orioles a 6-3 lead.

Mountcastle has been given the rookie treatment by his teammates — such as when they allowed him to take the field by himself in his first game — but he also has received their support.

“Most of the guys, a lot of the veteran guys, have taken me under their wing, giving advice,” Mountcastle said. “I know José Iglesias talked to me a bunch, Bryan Holaday, all these guys.”

César Valdez pitched two scoreless innings to pick up his first major league save.

Stewart, who is hitless in 16 at-bats this season, played for the first time since being recalled from the Bowie alternate site on Tuesday. He walked three times, struck out twice and was hit by a pitch. He has struck out 10 times and walked nine times.

“It’s going to come,” Hyde said. “He’s just got to continue to take, really, really good at-bats, and the results, if you’re working the process, the results will be there at the end.

“He’s going deep in the counts with a lot of his at-bats … He’s going to hit line drives and leave the ballpark sometime soon. Tonight, I thought he took great at-bats.”

Garcia pitched 4 2/3 innings, allowing four runs on five hits.

Coming up: The Orioles play the Yankees on Saturday at 7:35 p.m. Keegan Akin will pitch against Gerrit Cole. The Orioles haven’t named their starter on Sunday to face Masahiro Tanaka.