BALTIMORE—The Orioles had a fast start in the first inning of the first game of Thursday’s doubleheader against the Mariners, but their offense sputtered after that.

Trey Mancini hit a two-run home run in the first, and the Orioles did nothing offensively after that.

Reliever Tanner Scott gave up two runs in the sixth, and Seattle beat the Orioles, 4-2, in seven innings — the length of doubleheaders.

Scott walked José Marmolejos to begin the sixth, then struck out Luis Torrens and Taylor Trammell looking. Dylan Moore singled, and J.P. Crawford pulled a slider to right for a double, scoring pinch-runner Braden Bishop and Moore.

Manager Brandon Hyde was going to rest Mancini, and he was not in the lineup for Wednesday’s game that was postponed by rain. Hyde said Mancini showed a lot of frustration while doing hitless in Tuesday’s doubleheader split with the Mariners.

However, Mancini batted fourth in Game 1, and he hit a two-run home run against Marco Gonzales in the first inning for a 2-0 lead.

Orioles starter Matt Harvey gave up a two-run home run to Mitch Hanniger with two outs in the fifth. Harvey worked 4 2/3 innings, allowing two runs on three hits. He walked one and struck out three.

“I’m pretty frustrated,” Harvey said “I feel like that game should have been 2-0, and I should have been out there the whole game. After the second, I got nitpicky around the zone, and get behind some hitters.”

Harvey has thrown five innings in one start and 4 2/3 in the other two. He has a 5.02 ERA.

“Definitely feel good, feel strong, just have to eliminate those innings that are making the pitch count go up,” Harvey said. “I’ve got to keep working. Those mistakes can’t keep happening, especially in a close game like that. I’m pretty frustrated by that.”

After Mancini’s home run, Pedro Severino and Ryan Mountcastle singled, but Gonzales retired the next 10 Orioles until Freddy Galvis’ fifth-inning walk.

“We came out swinging the bat really well in the first,” Hyde said. “Marcos Gonzales, he’s been around for a while. He really settled in after that. We didn’t hit many balls hard.

“Really good first inning, and not much else after that to take pressure off our pitchers.”

Hyde said he’s pleased with Harvey.

“He was in total control in that fifth inning,” he said. “He’s kept us in the game three times. Now, we’ve got to swing the bats and get him some runs.”

Maikel Franco singled against Rafael Montero to lead off the sixth, but Mancini hit into a double play. Severino grounded to third to end the inning.

The Orioles went down 1-2-3 against Kendall Graveman in the seventh to drop to 5-7.

Mullins’ streak ends; Cedric Mullins was hitless in three at-bats. He had an 11-game hitting streak to begin the season, and a 15-game streak dating back to last season.

Sceroler injured: Rule 5 pitcher Mac Sceroler went on the 10-day injured list because of right shoulder tightness. The move was announced on Wednesday, but it’s retroactive to April 13.

“He’s just got some shoulder soreness,” Hyde said. “We’re encouraged by the test results, and we hope that it’s not going to be very long.”

Sceroler last pitched on April 11th, allowing three runs on five hits in one inning.

“He’s a young guy that tried to manage it,” Hyde said. “He did come in after his outing and said he was a little tight.”

Coming up: The Orioles play three games in Texas beginning Friday. Jorge López will face Mike Foltynewicz on Friday. Hyde said that Dean Kremer, who threw 54 pitches in three innings in Tuesday’s second game, was a possibility to face Dane Dunning on Saturday.

“He feels ready to go, so we’re going to consider that,” Hyde said about Kremer. Wade LeBlanc and Adam Plutko are also possibilities.

On Sunday, John Means will face Kyle Gibson.