A day after the Orioles broke their 20-game road losing streak, they suffered another lopsided defeat and lost their shortstop.

In the second inning of their 12-4 loss to the Toronto Blue Jays at Sahlen Field in Buffalo on Saturday, shortstop Freddy Galvis left the game after he reached first on a bunt single. He was diagnosed with a right quadriceps injury and taken for an MRI.

“I’m concerned,” manager Brandon Hyde said. “The way it happened and how it felt … The MRI results are pending. We’ll find out here shortly.”

Galvis needed assistance to get back to the dugout, was placed on a cart and later needed help to get into a car so he could be taken for the MRI. He was clearly in pain.

If the Orioles are without Galvis for a significant amount of time, they’ll suffer yet another key loss. They’ve been playing without a true second baseman this season, and Galvis has brought the kind of stability to the infield that Cedric Mullins has brought to the outfield.

Even though they’ve been struggling, the impact could be substantial. Their starting rotation has been reeling since John Means went on the 10-day injured list because of a left shoulder injury.

Hyde said the Orioles were making plans to add another infielder for Sunday’s game.

“It’s pretty upsetting, very good defender, veteran guy, you don’t want to see him go down like that,” starter Keegan Akin said. “Hopefully, he’s all right. We should know a little more tomorrow.”

Pat Valaika, who started at second, moved to short and Stevie Wilkerson played second. Both can play shortstop, but the team needs another infielder.

The Orioles have Domingo Leyba and Ramón Urias on the 40-man roster. Leyba, who was claimed on waivers from Arizona on June 4, has hit well at Triple-A but was hitless in 22 at-bats with the Diamondbacks.

Urias hit .248 with two home runs and eight RBIs in 25 games the Orioles earlier this season.

Akin (0-4) allowed six runs, including the two he left on base, on seven hits in 4 1/3 innings. Akin gave up four runs in the third. Bo Bichette’s RBI double accounted for the first run. Vladimir Guerrero Jr. hit a two-run home run, and Teoscar Hernández followed with a homer.

Guerrero has 26 home runs and has hit one in each of the three games against the Orioles.

“He threw the ball well for the first couple of innings and, in the third inning, he had a little trouble again,” Hyde said. “He’s got to be able to maintain that command throughout his outing.”

In the fifth, George Springer’s RBI single and Randal Grichuk’s three-run home run — off Konner Wade — put the Orioles behind, 8-0.

“I feel like I’m staying in one spot too much,” Akin said. “I’ve got to mix it up, back-and-forth, up-and-down. I made a couple of bad pitches and paid for it today. I’ve got to get better and get through that third inning. It seems like a common theme lately.’

Akin was replaced in the fifth by Wade, the 29-year-old journeyman whose contract was purchased from Triple-A Norfolk on Friday. Wade, like another seasoned rookie, Mickey Jannis, had a rough debut. He allowed six runs on seven hits in 1 2/3 innings. Jannis gave up seven runs on eight hits in 3 1/3 innings on Wednesday against Houston.

In the sixth, Toronto (39-36) scored four runs against Wade on a two-run single by Hernández and run-scoring singles by Springer and Grichuk.

Hyun Jin Ryu (7-4) picked up his second win against the Orioles(24-53) this week. On Sunday, he was the winner in a 7-4 Toronto win.

He allowed just two hits in the first six innings, singles by Austin Hays and Galvis’ bunt in the second.

Ryu gave up four runs in the seventh. Pedro Severino had a two-run single and Cedric Mullins had a two-run double.

Alexander Wells also made his major league debut, pitching two scoreless innings, giving up one hit.

Each of Toronto’s runs were scored with two outs.

Notes: Right-hander Mac Sceroler, who was chosen by the Orioles in December’s Rule 5 draft and was designated for assignment on Tuesday, has cleared waivers and been returned to the Cincinnati Reds. … Jorge López will face Ross Stripling on Sunday. … Wells is the third Australian to play for the Orioles. Right-handed pitcher John Stephens (2002) and left-hander Damian Holmes (2003) are the others. … The Orioles have used 43 players this season. … A report in The Athletic said that Trey Mancini had been invited to the Home Run Derby the night before the All-Star Game. “That would be a great experience for Trey,” Hyde said. “If he does have that opportunity, it would be a really cool moment.”

Who are these guys? Hyde has used several pitchers this year with whom he wasn’t familiar. He had little knowledge about Jannis or Wade. He knows Wells, who has been in spring training with the Orioles the last two years, though Wells didn’t pitch in Grapefruit League games because of injuries.

“I don’t think it’s that abnormal,” Hyde said. “Guys come up from Triple-A sometimes that you haven’t seen in the big leagues, and you’re going on the reports down there as well as.”

Orioles pitching coach Chris Holt talks regularly with Norfolk pitching coach Kennie Steenstra, and that helps.

“I’m going to throw them in there, and see what happens,” Hyde said.